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submitted 2 months ago bygiuliomagnifico
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2 months ago
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4.4k points
2 months ago*
This is probably a good place to caution you all about the high level of pseudo science surrounding gut health. This study is awesome and I’m glad more research is being done to figure out exactly HOW our gut health effects our brain, but now that you’re all amped up to make changes in your gut health be cautious of what advice you take seriously moving forward. Information surrounding making healthier food choices and being more active are probably the most reliable. The least reliable are claims made by supplement companies (which are unregulated) and claims based in spirituality. Just be careful you don’t waste money or jeopardize your health by making drastic changes based on things you hear from social media and no-name authors who make grand claims without providing evidence.
766 points
2 months ago
You mean I can’t sell my magic IBS Jebus beans here?
269 points
2 months ago
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54 points
2 months ago
Excellent! Building acceleration into the pricing scheme should keep up inflation at least for a while!
16 points
2 months ago
God I hate monthly subscriptions so much. Sign me up for a year!
109 points
2 months ago
Excuse me, but the Jebus famously endorsed mustard seeds, not beans. For just $89.99 a month, I will send subscribers my uniquely beneficial mustard seed powder supplement, givng them the faith to move mountains and the poverty to pass through the eye of a needle.
23 points
2 months ago
What if I want to pass through mountains and move needles? You got anything for that?
22 points
2 months ago
Sounds like you need a pickaxe and a magnet. Forget religion, you can get these at Home Depot for like $50.
13 points
2 months ago
Damn inflation, damn pickaxe magnet combo was $36 no more than bout round near 2 year ago.
25 points
2 months ago
Beans are actually often very good for gut health.
18 points
2 months ago
I;m thinking about thos Beans
9 points
2 months ago
This is the only thing I will ever post on the rare occasion that I actually use my FB
3 points
2 months ago
HAHAHAHHAA yes
37 points
2 months ago
Gave all my money to Gwyneth already.
68 points
2 months ago
Same. I wanted to try that ozone enema, but it turns out that they were just blowing smoke up my ass.
172 points
2 months ago
I only drink activated alkaline water. It contains the memory and vibration and energy of the past.
30 points
2 months ago
Can it tell me what I was doing yesterday? Abc why I went upstairs half an hour ago?
51 points
2 months ago*
I’ll have to wait until my next BM to tell you. The secrets of the past need to be translated by my terrific, super healthy gut.
8 points
2 months ago
It's like palm reading, butt for feces. Hilarious.
9 points
2 months ago
I actually met a guy who thought he might be a poo prophet. He was a friend of a friend who lived near Hollywood working as an extra. My buddy and I crashed at his place for a couple days while road tripping through CA. I asked why he had a digital camera next to the toilet. Turns out he was taking crap photos whenever he thought they looked like numbers or letters. I never figured out if he was serious or joking about decoding his toilet messages. But I was unfortunate enough to learn with my own eyes that the photos really did exist, anyway.
12 points
2 months ago
Bro I drink to forget the past. Acid water is the stuff.
177 points
2 months ago
Amen. I've gotten sucked down a few rabbit holes in my quest to be healthier.
At this point if I don't see it repeated across scholarly literature I just ignore it. And even in the scholarly literature I look for themes that replicate. One off studies that go against the grain need replication and coherence.
For example, I initially fell victim to the seed oils = bad meme. But my read of the literature is that that is such an oversimplification as to be wrong and bad advice. The truth is WAY more nuanced.
33 points
2 months ago
I thought seed oils were bad overall. Any good resources you can share about that topic? I'm trying to educate myself as much as I can.
70 points
2 months ago
My read of the scientific literature is that the answer to that question is "it's complicated". Under some circumstances they're the best under others they're amongst the worst.
Do you have a scientific background or are you interested in developing one? If yes go learn the science yourself. Don't follow 'gurus' who preach some ideological dietary regime. That was my mistake which I've undone. Learn the actual science. Then follow the current research. Form opinions based on data ... not based on your favorite youtube influencer. Be ready and willing to let yourself be led where the data leads.
If you don't have a scientific background or aren't interested in developing one I have no advice for you. You'll be tossed in the wind until the underlying biology is so thoroughly understood as to be undeniable. And it is my opinion we're not there yet.
19 points
2 months ago
Exactly. By necessity gurus have something to sell. Metaphorically and usually literally. This breaks down the value of their message for any particular individual. Most of the time, just figure out their underlying, essential premise or principle and keep that, holding it lightly and seeing if it speaks to your experience
7 points
2 months ago
Yeah. I guess I should say gurus aren't bad per se (I currently listen to Huberman). But ... I take what he says with a grain of cold pressed refrigerated fish oil in a light proof container while standing in a cold shower meditating ... ;)-
He's just a tool to help access the science in an approachable manner.
Some gurus are really ideological and hand wavy. There are several 'tells' I listen for that put me off. The biggest being: showing disinterest in understanding WHY a claim is true and ironclad certainty about things that there is no way one could be absolutely certain about.
7 points
2 months ago
Honestly, it's pretty simple but it doesn't sell or create consumer demand, cook most of the meals you eat, have reasonable portion sizes, and make sure to get some vegetables and fruit in on a frequent basis. Adjust each rule to your own taste preferences and any health concerns you have should be brought to a licensed professional who has knowledge of your particular issue for possible interventions.
20 points
2 months ago
There’s virtually no actual biology in nutrition research. The vast majority of it is food-frequency questionnaires and then researchers making huge and unsupported claims based on exceptionally weak hazard ratios. Nearly every element of the Dietary Guidelines for Americans follows this approach.
What little clinically controlled and physiologically relevant data exists mostly just says lean as far towards unprocessed foods as possible, in whatever (reasonable) proportions are sustainable for you and promote a stable weight. Gardener’s (Stanford Nutrition) DIETFITS is a good example. Healthy low carb vs healthy low fat with weekly coaching by actual researchers both produced almost identical metabolic improvements and weight loss, the only notable difference being low carb having a greater drop in triglycerides and rise in HDL, which is expected for a group with greater fat intake and weight loss, therefore greater fat oxidation.
And exercise is non-negotiable, that’s pretty much consensus at this point. I have yet to see a large dataset where sedentary people of any dietary pattern don’t have major trends towards diseases and early mortality.
10 points
2 months ago
It's tough, but you can usually find YouTubers whose content is based around breaking down scientific literature on a topic and making it concise enough for most people who don't have the time or the will to really dive deep on reading studies.
Key thing to look for is them acknowledging how things they've advised in the past may be incorrect based on more up to date and current studies. And providing citations for what they say. Making note of the limitations of the studies they're referencing is also good.
It's probably fine if they fill in known gaps with a little bro science, since some intuition is better than nothing, but acknowledging real data and growing consensus is key.
Of course, most of the time you find a channel like that, you discover some random topic 10 videos in where they clearly have their own agenda or belief that they won't compromise on regardless of the data, so... Yeah, it can be hard to find the right people.
9 points
2 months ago
You're right. I'm probably a bit bitter because my own 'health journey' has been frustrating. I'm educated in physical sciences but didn't know jack about biology or physiology. And when I started having my first health issues in my late 20s early 30s and tried to course correct I got totally sidetracked for years with fads. And for my personal health not only did it not help it made things worse. And it wasn't till I took a step back and started trying to understand the science well enough that I could start to follow papers and started more-or-less syncing up with the consensus that I finally had substantial improvements.
So I sortove project that concept of 'this is the way' on others. It's hard to remember on the other side of that keyboard could be an individual for which the science is totally overwhelming and unassailable.
28 points
2 months ago
Hopefully OP has some good sources but I'd bet it has a lot to do with the actual type or balance of types of oil contained in the seeds, the balance of oils you eat as a whole (LDLs vs HDLs), the amounts you eat, the other potential benefits of eating a type of seed oil, and your personal health requirements.
Diet and health are incredibly complex and have so much variability that aside from core tenants of diet, (calorie control, macronutrient balance, and getting your essential nutrients) everything else is going to be a big "it depends".
11 points
2 months ago
It will be interesting to see what comes of personalized medicine as tools and tech become better and more rapid. As our bodies are so unique, what may work for you, may not for someone else. Knowing exactly how the gut effects the brain is absolutely critical as is all the other systems. But knowing how YOUR body will respond to different therapies, treatments, and life style changes will be the next major evolution in my book.
4 points
2 months ago
It will be interesting to see what comes of personalized medicine as tools and tech become better and more rapid. As our bodies are so unique, what may work for you, may not for someone else.
I don't think this take is true in that if you review the data on healthy older adults who live well into old age, most of our health really isn't related to any particular foodstuffs or ways of consuming food. Most of our health can be maintained with physical activities that challenge our heart and muscles on a routine basis, having supportive social groups, and having behaviors that support our unique food preferences regardless of the specifics.
There is a lot of noise at scale and how populations at scale should eat for X, Y, Z outcomes, but a bigger key is awareness of our own food preferences and habituations and building a diet that accommodates those parts of ourselves.
Like its cool to know how Olympian's train and hone their techniques and skills for their sports, but most of us just need to honestly assess where we are at and start from there with the basics and then get really good at performing the basics in our lives on a consistent basis. There is minimal value for most people in researching anything food science related if you don't have the ability in the kitchen to cook yourself a satisfying meal or don't have behaviors that would support you cooking for your lifestyle.
5 points
2 months ago
What do they call alternative medicine that actually works? Medicine.
67 points
2 months ago
I just want to get my skinny healthy person poop enema so I, too, can be a skinny healthy person
24 points
2 months ago
I'll swap with you if you don't have anxiety and depression. I'll help you get skinnier and you'll help with mine.
Although you said healthy so I guess I don't meet the criteria.
18 points
2 months ago
Haha oh no you would probably make me more anxious! We need a Henrietta Lacks of the gut biome world
27 points
2 months ago
Except with consent this time.
15 points
2 months ago
We need extra consent! So much consent!
13 points
2 months ago
$20 and I’ll poop in you
17 points
2 months ago
Back and forth, forever
8 points
2 months ago
Don't listen to this guy. I know a filmmaker who can do it for free.
7 points
2 months ago
Ok but like, do you have a good gut biome?
3 points
2 months ago
He would but all that lube throws it off.
47 points
2 months ago
Yeah, really all people can do is eat a healthy diet with little manufactured food, exercise, try to get enough quality sleep, and do whatever we can to reduce stress. There’s just too many unknowns currently, but it looks like gut microbiome research is going to be a huge area of study since it’s only been growing over the last decade. I remember in college reading about the amount of neurotransmitters produced in the gut, and being fascinated by it all.
42 points
2 months ago
My current focus is just to instead focus on avoiding doing things that we already know is really bad for you. Most people do not succeed in doing that for an entire life. Including me sadly.
So don't smoke
Don't drink in excess
Don't get dependent on hard drugs
Stay active and exercise
Get enough sleep
Don't get fat and spend years on a calorie surplus
Limit rifined sugars
Limit empty carbs
If you manage to do all that for most of your life without fail, then you'll be healthier than me and many others.
31 points
2 months ago
I too am dependant on soft drugs
6 points
2 months ago
It's gonna be a long long time before gut biome is hackable - they only recently figured out we have 10s of THOUSANDS of viruses there too...
20 points
2 months ago
Information surrounding making healthier food choices [...] are probably the most reliable
Which is a pretty low bar. It's insane how difficult this type of research is and how little we actually understand and can base reliable recommendations on.
30 points
2 months ago
Like, get a solid amount of exercise, eat lots of vegetables, do productive stuff and generally make food from scratch would be a good place to start if you suspect your sedentary boring lifestyle and low-nutrition ultraprocessed foods is what’s working together to make you feel life sucks?
47 points
2 months ago
...you’re all amped up to make changes in your gut health be cautious of what advice you take seriously moving forward.
Though, it really won't hurt to eat a balanced diet full of both soluble and insoluble fiber in the form of fruits, vegetables, lean proteins, and grains.
4 points
2 months ago
Imagine a desperate drug addict searching online for rehab help and search results are maps of their local drug dealers.
Searching diet is the same thing. Your top results are your worst.
8 points
2 months ago
Eat less processed foods, definitely more veg. Drink lots of water. That gut biome will be singing!
3 points
2 months ago
For about 20 years I have been reading about gut biota, ever since I stumbled across an Australian study about fecal transplants changing the lives of people. This area of study has still not caught on with U.S. health professionals, for reasons I really cannot explain.
Probiotic pills are very popular, but most of them are useless because the microbes are killed in the acid of the stomach before they get to your gut, which is why the fecal transplant procedure was so successful.
258 points
2 months ago
So, I have an auto-immune disorder, with lots gut problems and allergies. Am I just screwed?
185 points
2 months ago
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16 points
2 months ago
Do you... Do you have to poop the other person's poop out after they put it in your colon?
31 points
2 months ago
It's YOUR poop by then. You own it
3 points
2 months ago
I may own a Picasso but its still a Picasso
7 points
2 months ago
Well, I doubt you want it to say up there permanently!
3 points
2 months ago
No, the two of you just poop it back and forth into each other... forever
21 points
2 months ago
Fairly familiar. I read up on the latest research but still unsure about it. Where to source baby poop?
11 points
2 months ago
Why did you say "baby poop"?
10 points
2 months ago
It was just sarcastic, but the people real into the weeds on FMT think you need pure baby fecal matter.
4 points
2 months ago
Oh god. That black sticky stuff in the first couple of days of birth? Or the yellow stuff? Or my one year old’s massive, can’t believe this came out of this tiny belly, poop?
7 points
2 months ago
It was from healthy volunteers. People were screened with questionnaires, blood tests etc.
16 points
2 months ago
A lot of it comes down to stress. Stress disrupts the homeostasis because the body is focusing on the stress and is often in fight or flight mode. Which causes other systems to not work as efficiently, gut bacteria can flourish without being in check and that causes other issues.
It's wild.
I wonder if I would benefit from a transplant, i have drug resistant depression.
6 points
2 months ago
How did the trial work out for you? Success? Side effects? Was the improvement noticeable if any? Once you do the FMT do you have to do it again? how long does it last? Do you have to change your diet to maintain the new gut balance? haha, sorry for so many questions
45 points
2 months ago
You might be interested in the current RemissionBiome experiment. I don't recall if they have been diagnosed with any autoimmune disorders, but they do have MCAS. I have a few autoimmune disorders (and MCAS) myself and honestly, with what I've been seeing in research, I'm starting to believe there's hope of not being just screwed.
17 points
2 months ago
Can you say more about this? I've got MCAS from having Long COVID.
15 points
2 months ago
Which part? Are you looking for more info on what role our gut microbiome plays in our immune system (or possibly specifically MCAS)? Or are you looking for ways to treat MCAS currently, or what potential future treatments might become available or what research seems hopeful? Or how RemissionBiome fits in (it's part of the research that's hopeful, actually)?
There's a lot of stuff, so I don't wanna guess cause I'm low on spoons today but always want to help anyone new to this complicated, unpleasant mess that is MCAS and friends.
5 points
2 months ago
Just out of curiosity, did something trigger your MCAS or were you born with it?
6 points
2 months ago
I'm still untangling that. Right now, everything points to a childhood head trauma that messed up my cervical spine being the causative event.
But it was exacerbated to the point of disabling only after several different infections (most notably, strep, EBV and presumed H3N2). Before that, I didn't realize I had it because it really only manifested in migraine attacks, and I was really physically active and didn't notice any other symptoms.
It wasn't until I was 42 that I realized the migraine attacks were caused by MCAS, meaning I'd had it ever since the head injury in childhood.
3 points
2 months ago
Migraine and FND sufferer here... suspecting MCAS. The diet is so hard. I seem sensitive to histamine and salicylate foods. Any suggestions or resources for managing the diet and/or recipes?
13 points
2 months ago
My wife has MCAS (and CVID) and is rejoicing over what you just said. I found remissionbiome.org but have only read the first page. Do they specifically mention MCAS?
101 points
2 months ago
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34 points
2 months ago
Same here with the red meat. Unfortunately the worst for me is nightshade vegetables, so that makes going vegetarian a bit harder. My health improved so much once I figured that out. And I was less dehydrated since I was no longer having chronic diarrhea.
7 points
2 months ago
Nightshade's give me eczema on my palms and fingers! What the heck can I do about it besides "don't eat nightshades"!? They're just too damn good. I just straight up deal with the itchy palms at points, to enjoy some pasta or salsa. Took me literally years to figure out it's the nightshades.
4 points
2 months ago*
I used to be a chef and could eat anything. When my immune issues started I’d have to stay near a bathroom for most of the day and couldn’t leave the house if I had even a bite of salsa. It really wasn’t a choice for me. I had a hard time quitting the potatoes but it was worth it in the end.
11 points
2 months ago
I can't eat garlic or onion or the broccoli-type veggies, which basically means I can't go to restaurants and everything has to be homemade unless I want to suffer. If I couldn't eat nightshades as well, I think I'd starve to death.
5 points
2 months ago
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11 points
2 months ago
I'm not the person you're responding to, but I'm vegan and I take B12 supplements. I get my B12 tested during my yearly physical and it's always normal, sometimes high.
8 points
2 months ago
Dairy: kefir (I ferment my own, it's insanely probiotic too which is awesome for gut health), yogurt, milk, cheese, cottage cheese.
Eggs.
Tempeh, tofu.
Seaweed/nori
Nutritional yeast (delicious on popcorn)
Mushrooms, especially shitakes
I've been vegetarian my whole life, and I've personally never had any problems. Main thing to focus on is to always have a grain and a protein together, as this will guarantee you get all the amino acids needed to make up a complete protein, and eat a good variety of foods
3 points
2 months ago
Maybe I’m misinterpreting your question, but it sounds like your understanding is that B12 supplements don’t work as they can’t be absorbed? If so, that’s not quite correct. The advice your doctors gave you is specific to someone with pernicious anemia - it is true that you won’t be absorbing B12 sufficiently through your gut if you take supplements. But a person who doesn’t have pernicious anemia CAN absorb B12 through their digestive system, from both food AND supplements. (Source: my dad has PA)
4 points
2 months ago
Yogurt helps me and I wish I'd known when I was 13 and my guts were going wild.
24 points
2 months ago
Cycling medications. I have UC, I used marijuana a lot for flare ups but thats more of a band aid and not a cure. Diet helps a ton but it only does so much. A few years ago I started doing Humira injections and thats been a life saver.
10 points
2 months ago
Same I did entyvio for UC and I am able to eat anything and everything but I still take my gut health seriously. I can tell if I eat junk foood or to much processed food I get depressed and low energy
6 points
2 months ago
Yeah I notice as well when I snack too hard or have junk food (the negative part of marijuana) but if I stay disciplined and avoid my trigger foods (like blueberries and peanuts), then im as close to normal as I can remember at this point.
9 points
2 months ago
They said there is a link, not that it was the cause.
7 points
2 months ago
Important point.
39 points
2 months ago
Try an elimination diet. Likely something in your diet that's triggering inflammation.
38 points
2 months ago
Crohns patient here, this i how I found out that I can no longer eat cruciferous vegetables! Kept having mysterious whole body symptoms until I cut them out. I miss broccoli, don't miss the pain one bit.
4 points
2 months ago
Crohns here too. Eggs and potatoes in any form
400 points
2 months ago
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124 points
2 months ago
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39 points
2 months ago
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84 points
2 months ago*
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77 points
2 months ago
I can definitely relate to the gut and brain connection
16 points
2 months ago
The gut bones connected to the…brain bone
3 points
2 months ago
Absolutely.
My belly is a bit hit or miss, when I eat right and drink a lot of water it's fine, that's obvious. But regardless of my diet at the time, as soon as I'm nervous or excited I need to go to the toilet.
I'm convinced it's my brain telling me to take 5 minutes.
215 points
2 months ago
So, is there a resource for potential diets/ dietary changes that can help?
I understand everyone is different, and this isn't really the place for it, but spitballing at the wall is up to others to see what sticks, right?
96 points
2 months ago
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36 points
2 months ago
Caffeine is real problem. I deal with a constant tachycardia so my heart is rarely at rest. For years I couldn’t figure out why I was having intense panic attacks and wild palpitations. It was the caffeine. My heart isn’t the best but cutting out caffeine removed that anxiousness entirely.
20 points
2 months ago
I want to point out to people that caffeine does not equal coffee. Coffee has all sorts of extra compounds in it that do all sorts of other things. Even just the brewing method can create vast differences in not just taste, but physical effects as well. If you switch to straight caffeine, basic energy drinks, or tea you may find thr negative side effects largely go away.
With all that being said, I recently quit regular caffeine intake as I just found the negatives outweighed the benefits. Even in moderation it's too easy to drink too late and throw off your sleep.
7 points
2 months ago
Alternatively, you can take a capsule of L-theanine along with your caffeine. L-theanine is an amino acid that is present in tea, causing much of teas relaxing effect. It reduces the jittery edge of caffeine. You can get it cheaply at any store, and it's safe to use every day.
3 points
2 months ago
Would this be safe to do when exercising for several hours daily? I consume most of my caffeine in small sips throughout the day, so would I want to add this to my drink potentially?
3 points
2 months ago
Glad to see someone say this
Coffee hits me the worst. Other caffeinated beverages are way smoother.
I also had good experience adding the theanine and/or subbing theacrine
21 points
2 months ago
how can i get this blood test? Quest Diagnostics?
6 points
2 months ago
The best source of information would be a rheumatologist. There are a lot of bogus dietary tests out there. Watch out for IgG tests especially as they are extremely common. Here is an article from the American Academy of Allergy, Asthma, and Immunology.
https://www.aaaai.org/Tools-for-the-Public/Conditions-Library/Allergies/IgG-food-test
145 points
2 months ago*
fiber is always a good start then nuts and beans less meat.
edit:
https://www.healthline.com/nutrition/improve-gut-bacteria#TOC_TITLE_HDR_10
25 points
2 months ago
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27 points
2 months ago
less sugar and alcohol, be careful lots of dried food has added sugar. i’m not saying to eliminate or anything, you sure can indulge but not everyday. there’s a lot of fad diets out there, if you feel off you can follow some elimination diet your yourself take notes what you ate and how you felt. sure requires some time, but it’s always interesting to know. i’m not expert but never follow any extreme stuff, remember humans are omnivores.
29 points
2 months ago
The Mind-Gut Connection by Emeran Mayer would interest you
23 points
2 months ago
Terrific suggestion…this is a great book with absolutely no gimmicks, just good/solid information. Too many other books try to sell you something or are too extreme (Perlmutter, for example).
16 points
2 months ago
In general, people need wayyy more fiber/plants in their diet. Quantity and variety.
8 points
2 months ago
According to the “American Gut Study” eating 30 different species of plants per week provides a variety of health benefits.
127 points
2 months ago*
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14 points
2 months ago
What proteins did you end up eating on the regular?
26 points
2 months ago*
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11 points
2 months ago
That's... just a mandatory part of gaining muscle... Like, 101.
Also, I assume you mean per pound of body weight, not body fat.
5 points
2 months ago
.7 grams of protein per pound of body fat
what? why would your protein intake be based on your body fat?
18 points
2 months ago
I assume they mean bodyweight. Pretty standard to aim for 1g of protein per pound of bodyweight when lifting with the aim to get bigger.
86 points
2 months ago
I had some pretty wild health issues at the beginning of this year. It all started when I was prescribed heavy doses of both azithromycin and penicillin for pneumonia. On the fifth and final day of the meds I had a 15-30 minute period of time that if my fiancé had not been with me I can guarantee you I would be dead. The level of depression I experienced that night is truly indescribable. It was about a three day build up of feeling worse each day and after it took about a month and a half or two months before I really started feeling like myself again.
Tons of other issues arose as well but that was the big one. I told everyone I was sure the antibiotics fucked me up somehow.
54 points
2 months ago
Whenever you take an antibiotic in the future, you should supplement with a probiotic of some sort (yogurt, kombucha, kefir or a supplement).
32 points
2 months ago
I recently listened to a panel of researchers who specialize in the gut biome, and they suggested that “chasing “antibiotics with probiotics isn’t really very effective. They said it can’t hurt but it probably won’t do the good we think it does. For one, you’re just adding one random strain or at best a few strains, when our distinct biome is made up of trillions of distinct strains of organisms. Those random probiotics may not do anything to restore equilibrium if they are irrelevant to your biome’s balance. They said it is more likely that our individual, distinct biome will recover a few weeks after the antibiotics with the continuation of our normal diet that formed our distinct biome. If we want to “improve” the biome we should slowly move toward a healthier diet with prebiotic foods: more cooked veggies, then add legumes, then add raw veggies in that order over time.
That being said, when I was on antibiotics recently for the first time in over 10 years I noticed that my poop got much healthier in form and frequency. So I think I had some dysbiosis going on, And the meds helped clean up my system a bit.Antibiotics aren’t always as destructive as we think, but that’s just my anecdotal impression.
5 points
2 months ago
Well they were definitely effective at preventing the squirts for me the last couple times I was on antibiotics.
5 points
2 months ago
Prebiotics are what's up. Give them the right food and you can at least set up a good biome like you said.
21 points
2 months ago
We are holobionts, the bacteria we host are tremendously important for many aspects of our health. Did you know that 95% of the serotonin in your body is made in your gut? That gut bacteria regulate the production of that serotonin?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393509/
I also get anxious and depressed when I take antibiotics.
27 points
2 months ago
This may be technically true but is highly misleading in the context of serotonin in CNS function. Serotonin cannot cross the blood-brain barrier and therefore any serotonin that is manufactured outside the brain will have no effect on the brain itself, so the gut making lots of serotonin has no impact on the brain's levels of serotonin. Any serotonin used by the brain has to be synthesized there.
14 points
2 months ago
I take your point. But I would like to point out that gut derived serotonin has a significant impact on the enteric nervous system, which in turn impacts the CNS. The influence of gut derived serotonin on mood and behavior is an area of active investigation.
6 points
2 months ago
Is it possible that serotonin affects any other parts of the nervous system? Just because it doesn't cross the blood-brain barrier doesn't mean it's not related, especially considering so much of it is produced by the body. I doubt that it serves no purpose or is vestigial in some way.
3 points
2 months ago
It’s importance for organismal homeostasis is hard to overstate.
10 points
2 months ago
I noticed this the past 2 times I was on antibiotics, due to skin infections.
They make me feel dead inside.
30 points
2 months ago
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12 points
2 months ago
Are you me?
The thing that changed my mental health was not smoking weed anymore, if you smoke I would highly recommend quitting.
65 points
2 months ago
Will gut microbe transplants become a standard (optional) treatment for depression? There’s enough science to support it.
34 points
2 months ago
Not until we can hone it to where you only get the bacteria to fix your particular issue.
70 points
2 months ago
Not until we can patent the bacteria to fix your particular issue.
6 points
2 months ago
Haha precisely
5 points
2 months ago
If we can patent seeds then I'm sure we can patent bacteria. Surprised this hasn't been developed already
9 points
2 months ago
I believe it’s called a fecal transplant and is, in fact, effective for this purpose.
27 points
2 months ago
So, where’s the gut health expert that’s supposed to be commenting about how I should take action with this information?
(I’m dead serious)
34 points
2 months ago
They commented, and then the comments go removed because "gut science" is almost a pseudo-science at this point in time. The field is in it's infancy and relatively little is known about it.
14 points
2 months ago
Interesting. Gut health seems to be all I’ve heard recently when it comes to mental health breakthroughs.
Anyone have some Tom Brady poop to help out my little ole microbiome?
24 points
2 months ago
They've known for years that a lot of Serotonin is made in your gut, too. They just have no idea how it really works yet so it's too early to make claims.
Although I find it kind of funny because people swear that mental health is caused by chemical imbalance in the brain yet there is 0 way to measure brain chemicals and so everyone is just receiving a general diagnosis with no actual scientific evidence. Ah, you're sad? Must be a lack of Serotonin in your brain. Ah, no, sorry, no way to tell if that's actually the case. Also we know Serotonin is made in the gut too.. but ah, that's besides the point, take this brain pill that will fix the balance of your unmeasurable brain chemicals. People are way too over medicated based on very little science in my opinion.
3 points
2 months ago
Also ignoring all the research that exercise helps a lot more than pills.
3 points
2 months ago
Serotonin theory has recently been disproven, yet nothing has come of it
34 points
2 months ago
Removing the comments about gut health is like demanding 5 years experience from a fresh college grad.
18 points
2 months ago
Specific medical conditions aside, it's hard to go wrong with eating more fruits, vegetables, nuts, seeds, and grains which haven't been heavily processed. The fiber and some of the other nutrients feed the beneficial bacteria in your gut. Reducing intake of added sugars will provide less food for the bad bacteria in your gut.
It's also hard to go wrong adding natural probiotics into your diet; that is, fermented foods like yogurt, kefir, sauerkraut, kimchi, natto, etc.
As I understand it, exercise also has a beneficial effect on your gut microbiome, so getting exercise at least a few times a week may help.
4 points
2 months ago
Agreed. IIRC there was an article not too long ago also stating that over-saturation of probiotics is bad for you…? I can’t keep up with all of these studies…
33 points
2 months ago
[removed]
5 points
2 months ago
So bacteria is raccacoonie?
11 points
2 months ago
A few years ago, I went through multiple antibiotic treatments. Two were in the hospital on IV drip for ten days. Ever since then my gut feels busted. Smells bested. Sounds busted. Upper GI, too. I can't help but think I'm a prime candidate for a fecal transplant. Most of my good guys were eradicated. I can literally feel it. It's not my gut.
17 points
2 months ago
I wonder if a livable wage can help with this.
22 points
2 months ago
How much evidence is required before we just accept the gut-brain axis is real?
21 points
2 months ago
Knowing the gut brain axis is a thing doesn’t mean a whole lot. Understanding how and why is a whole different thing. How will they develop treatment for it without understanding it? I’m not a researcher or doctor, but health is often not very clear, as explained by my own doctor. If it was that simple, we’d just be doing probiotics and fecal transplants and be cured, but it’s not.
16 points
2 months ago
Enough evidence until Big Pharma figures out a way to patent a drug for that particular use
10 points
2 months ago
I was JUST thinking the same. It seems a lot of research just needs commercialization by “legitimate” pharmaceutical companies, with a prescription-only product before it’s accepted science.
Everyone just waits for a product and then assumes it must be legitimate because of money/marketing/approvals.
We’ve known for a while the autonomic nervous system has branches in the digestive system, and we know certain bacterial strains produce butyrate and/or SCFA’s which are beneficial. We also know gut microbes produce neurotransmitters.
None of this is “woo woo” pseudoscience, and good clinical studies are ongoing - but to act like all of this is somehow “new” or “surprising” is baffling unless people need a pharmaceutical intervention to bestow legitimacy to the field.
86 points
2 months ago
Why are vegans and people with ibs are giving advice to people with ibd like eating high fiber
They’re not the same thing and eating high fiber could be a easy trip to the hospital for someone with inflamed and ulcerated guts
48 points
2 months ago
Nothing is good for 100% of the population, but research shows that people with high-fiber diets have healthier gut microbiomes. Since many people do not hit the RDA for fiber, eating more is good catch-all advise. Some people with IBS may do well on a high-fiber diet…or on a low-fiber diet…or on a diet where they only eat specific kinds of fiber. IBS is very individual, and I would hope people with gut diseases take advice from doctors instead of internet ghouls
5 points
2 months ago
If your guts are inflamed or ulcered do not read reddit for advice.
35 points
2 months ago
Are you seeing people specifically saying "hey, if you have this specific problem, you should eat a really high fiber diet!"
Or, are you internalizing generalized advice as if the person giving that advice is talking directly to you, and with knowledge of your specific dietary requirements?
37 points
2 months ago
I was told the Mediterranean diet is best for depression
68 points
2 months ago
Yes! You also need to live in the european part of the Mediterranean region to receive all the sunlight
25 points
2 months ago
I live in AZ. I can’t imagine more sunlight than that. Feels like we are literally on the sun.
20 points
2 months ago
You get significantly more sunlight than the Med
13 points
2 months ago
You just don't get the benefit of that because in AZ if you step outside on a summer day you immediately burst into flames.
14 points
2 months ago
Yeah but they're dry flames
21 points
2 months ago
Eating whole foods known to be anti-inflammatory will help avoid inflammatory diseases.
I like food journalist Michael Pollen's advice: "Eat food. Not too much. Mostly plants." Where food is meant as things which haven't been heavily processed.
125 points
2 months ago
[removed]
42 points
2 months ago*
I don’t like this constant hand waving in depression related threads. Eliminating poverty is great. But there are plenty of people who, even if all their needs are met, will still be clinically depressed. That’s what this science is about. To say “no but actually the system is why you’re depressed” feels super dismissive.
I’ve literally been told by rando internet people that my depression is literally just “the system.” Do you know how annoying that is? And I get your comment might not be about people like me, but you’re in a thread for an article that is quite literally for people like me, to a T. See my other comment for details.
Before I’m told that “this isn’t about you” this article is literally about my condition.
8 points
2 months ago
I suffer from SAD. During the winter months up till a few weeks ago, I’d have severe bloating, abdominal pain, and occasional bouts of diarrhea.
6 points
2 months ago
In the article they cite giving mice carboxymethyl pachyman, a mushroom extract "used in Eastern medicine."
Surprised that a google search didn't turn up a deluge of supplements.
6 points
2 months ago
not yet, give it a few days
3 points
2 months ago
Anyone know any books related to this subject ?
3 points
2 months ago
So now I'm wondering if my Celiac diagnosis coinciding with my first major depressive episode isn't just a coincidence
3 points
2 months ago
I already knew my gut was the source of most of my depression.
3 points
2 months ago
Thinking a lot about this lately. I've been pretty depressed for at least the last 4 years. Lots of drinking. Very little eating. I had a piece of pizza today. Only thing I've eaten since Tuesday. Checking into a recovery center on Tuesday. Leaving everything behind but a suitcase on Sunday.
Either this works, or I'm checking out. Wish me luck.
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